Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes.
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چکیده
منابع مشابه
Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes.
We investigated the binding of 125I-labeled alpha-inhibin-92 (a 92-residue peptide) to human pituitary membrane preparations. Unlabeled alpha-inhibin-92 competed effectively with the labeled peptide for binding to the membranes. Binding was also inhibited by both alpha-inhibin-52 and alpha-inhibin-31, but less effectively. Scatchard analysis of the alpha-inhibin-92 binding data indicated the pr...
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A 92-amino acid polypeptide, alpha-inhibin-92 (alpha-IB-92), has been isolated and characterized from human seminal plasma and found to be active in suppressing follicle-stimulating hormone (FSH) release in vitro. In the present in vivo study, intravenous injection of synthetic alpha-IB-92 (4 and 20 micrograms) significantly suppressed FSH release (P less than 0.001), whereas this peptide had n...
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Employing a 3 step purifICation procedure follicle stimulat ing hormone (FSH}-suppressing factor, desJgn.lCd "inbibin, w" purified to homogeneity from human IItmin.1 plasma(HSP). The ethanol/etherutract ofHSP was chrorMtoanpbcd 00 Sep~du G-IOO column. The' biologically adive fraction duted was electrophoresed on Pevilum block lODe electropbo~i. and sut-qucntly isolIIted in pure fonn on a OEAE.(...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1987
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.84.11.3595